NFL odds, lines, spreads: 2025 Week 18 picks, predictions from proven model: 5-way parlay pays nearly 25-1

The NFL playoff matchups will take shape in NFL Week 18. The top seeds in both the AFC and NFC are still at stake, as is who is going to take the NFC South title and the playoff spot that comes with it. The winner of the Seattle vs. San Francisco game will get the top seed in the NFC, while Denver is one win away from being the top seed in the AFC. If the Broncos falter against the Los Angeles Chargers, New England can take top honors with a win over Miami. 

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There are a number of solid matchups on the Week 18 NFL schedule, including two on Saturday with Panthers vs. Buccaneers (-3) and Seahawks vs. 49ers (-1.5). The rest of the slate is Sunday, including Colts vs. Texans (-10.5), Packers vs. Vikings (-6.5), Lions vs. Bears (-2.5), Chargers vs. Broncos (-7.5), Dolphins vs. Patriots (-10) and Commanders vs. Eagles (-8). The Ravens (-3.5) face the Steelers on Sunday Night Football at Pittsburgh.

Before locking in any NFL bets, make sure you see what SportsLine's advanced computer model has to say. 

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model entered Week 17 on a 53-37 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!

The model has scoured the Week 18 NFL odds and locked in five confident NFL best bets. If you successfully parlay its sports betting picks, you'd be looking at a massive payout of nearly 25-1. 

One pick we'll give away: The model is backing the Seahawks (+1.5, 49.5) to cover against the 49ers nearly 60% of the time.

The model is also backing a surprising underdog that it says will cover in a tight matchup! You ABSOLUTELY NEED to see its NFL picks for every game before you make any NFL bets of your own!

So which NFL teams should you back in Week 18, and which five picks should you lock in RIGHT NOW? ... Join SportsLine now to see who wins and covers every single NFL game this week, all from the model on a 53-37 roll on top-rated NFL picks!

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