NFL odds, lines, spreads: 2025 Week 17 picks, predictions from proven model

There are numerous games on the Week 17 NFL schedule that carry no postseason ramifications, but that doesn't mean these matchups carry no interest for those making Week 17 NFL picks. With some teams giving younger players opportunities, the NFL odds posted at sportsbooks could be way off. Contests such as Cardinals vs. Bengals (-7), Saints vs. Titans (+2.5) and Giants vs. Raiders (+1.5) all fit the bill as under-the-radar games that could find their way onto your Week 17 NFL betting slip.

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Meanwhile, New England (-12.5) is the biggest Sunday favorite as it visits the Jets. It's one of five games with a Week 17 NFL spread of at least a touchdown, while one of the slimmest lines is a potential Supe Bowl preview in Bills vs. Eagles (+2.5) on Sunday at 4:25 p.m. ET. Another possible preview of the postseason then takes place later that night with the 49ers as 2.5-point favorites over the Bears, per the Week 17 NFL odds.

Before locking in any NFL bets, make sure you see what SportsLine's advanced computer model has to say. 

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model entered Week 16 on a 52-37 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!

Now, the model has evaluated the latest NFL odds, simulated every snap for Week 17 of the 2025 NFL season, and the results are in.

We can tell you one of the model's strongest Week 17 NFL picks is that the Steelers (-4.5, 34.5) cover versus Cleveland on Sunday at 1 p.m. ET. The model has Pittsburgh prevailing versus the spread nearly 60% of the time. Another one of its Week 17 NFL predictions: the Raiders (+1.5, 42.5) cover versus the Giants in well over 50% of simulations in a Sunday kickoff at 4:05 p.m. ET. The model also says the Over hits well over 50% of the time.

The model has also made the call on who wins and covers in every other NFL game this week and just revealed SEVEN teams that outright win nearly 70% of the time or more! You ABSOLUTELY NEED to see its NFL picks for every game before you make any NFL bets of your own!

So which NFL teams should you back in Week 17, and which seven teams should you lock in RIGHT NOW? ... Join SportsLine now to see who wins and covers every single NFL game this week, all from the model on 52-37 roll on top-rated NFL picks!

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