NFL odds, lines, spreads: 2025 Week 16 picks, predictions from proven model: 5-way parlay pays nearly 25-1

The NFL playoff picture will begin to take shape as the NFL schedule enters Week 16. The NFC North Division title may be on the line on Saturday night when Jordan Love and the Green Bay Packers take on Caleb Williams and the Chicago Bears. The Bears hold a half-game lead over the Packers in the division. Green Bay is a 1.5-point road favorite and is 3-6-1 against the spread in its last 10 games, while Chicago is 7-2-1 ATS in its last 10. The Packers won the last meeting, 28-21, in Green Bay on Dec. 7, and have won nine of the past 10 meetings with the Bears. Green Bay will be without several starters due to injury, including pass rusher Micah Parson (knee) and possibly wide receiver Christian Watson (chest).

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There are a number of other solid matchups on the Week 16 NFL schedule, including Rams (-1.5) vs. Seahawks on Thursday Night Football; Buccaneers (-2.5) vs. Panthers, Jaguars vs. Broncos (-3) and Steelers vs. Lions (-7) on Sunday; Patriots vs. Ravens (-2.5) on Sunday Night Football; and 49ers (-5.5) vs. Colts on Monday Night Football.

Before locking in any NFL bets, make sure you see what SportsLine's advanced computer model has to say. 

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model entered Week 16 on a 50-35 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!

The model has scoured the Week 16 NFL odds and locked in five confident NFL best bets. If you successfully parlay its sports betting picks, you'd be looking at a massive payout of around 25-1. 

One pick we'll give away: The model is backing the Broncos (-3, 45.5) to cover against the Jaguars well over 50% of the time.

The model is also backing a surprising underdog that it says will cover in a tight matchup! You ABSOLUTELY NEED to see its NFL picks for every game before you make any NFL bets of your own!

So which NFL teams should you back in Week 16, and which five picks should you lock in RIGHT NOW? ... Join SportsLine now to see who wins and covers every single NFL game this week, all from the model on a 50-35 roll on top-rated NFL picks!

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