NFL odds, lines, spreads: 2025 Week 16 picks, predictions from proven model: 5-way parlay pays nearly 25-1

The NFL playoff picture will begin to take shape in NFL Week 16. We've already seen the Eagles lock up the NFC East and the Bears move closer to clinching the NFC North, in games on Saturday, with Sunday sure to provide just as much excitement with several pivotal contests.

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There are a number of other solid matchups on the Week 16 NFL schedule, including Buccaneers (-3) vs. Panthers, Jaguars vs. Broncos (-3) and Steelers vs. Lions (-7) on Sunday; Patriots vs. Ravens (-3) on Sunday Night Football; and 49ers (-5.5) vs. Colts on Monday Night Football as Philip Rivers will play in front of a home crowd in Indy.

Before locking in any NFL bets, make sure you see what SportsLine's advanced computer model has to say. 

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model entered Week 16 on a 52-37 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!

The model has scoured the Week 16 NFL odds and locked in five confident NFL best bets. If you successfully parlay its sports betting picks, you'd be looking at a massive payout of around 25-1. 

One pick we'll give away: The model is backing the Broncos (-3, 46.5) to cover against the Jaguars well over 50% of the time.

The model is also backing a surprising underdog that it says will cover in a tight matchup! You ABSOLUTELY NEED to see its NFL picks for every game before you make any NFL bets of your own!

So which NFL teams should you back in Week 16, and which five picks should you lock in RIGHT NOW? ... Join SportsLine now to see who wins and covers every single NFL game this week, all from the model on a 50-35 roll on top-rated NFL picks!

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