It's the more, the merrier with Week 15 NFL picks as every team is in action with no one on a bye. But there's not just quantity that you can make NFL best bets on, as there is a high quality of contests as well. There are six games with playoff implications for both teams involved, including Chiefs vs. Chargers (+4.5), Bills vs. Patriots (+1.5), Packers vs. Broncos (+2) and Rams vs. Lions (+5.5). For some of these squads, these are must-win scenarios, and that should only increase one's interest to lay down Week 15 NFL bets.

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The largest lines, per the Week 15 NFL odds have the 49ers at -12.5 versus Titans, as well as the Eagles at -12.5 against the Raiders. Meanwhile, if interested in making over/under NFL predictions, one game stands out as Lions vs. Rams has a total of 55 points, making it one of the highest of the 2025 NFL season.

Before locking in any NFL bets, make sure you see what SportsLine's advanced computer model has to say. 

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model entered Week 15 on a 50-35 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!

Now, the model has evaluated the latest NFL odds, simulated every snap for Week 15 of the 2025 NFL season, and the results are in.

We can tell you one of the model's strongest Week 15 NFL picks is that the Saints (+3, 40.5) cover at home versus Carolina in a Sunday 4:25 p.m. ET kickoff. The model has New Orleans prevailing versus the spread well over 60% of the time, with the Over hitting in over 60% of simulations in an A-rated pick. Another one of its Week 15 NFL predictions: the Giants (-2.5, 47.5) cover versus the Commanders in over 50% of simulations in a Sunday kickoff at 1 p.m. ET.

The model has also made the call on who wins and covers in every other NFL game this week and just revealed THREE underdogs projected to outright win! You ABSOLUTELY NEED to see its NFL picks for every game before you make any NFL bets of your own!

So which NFL teams should you back in Week 15, and which three teams should you lock in RIGHT NOW? ... Join SportsLine now to see who wins and covers every single NFL game this week, all from the model on 50-35 roll on top-rated NFL picks!

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