NFL odds, lines, spreads: 2025 Week 13 picks, predictions from proven model

The Browns haven't done much winning over the last few decades, but they are head and shoulders above all other teams in one way entering the Week 13 NFL schedule. Cleveland is undefeated versus the spread at home (4-0), making them the only team that can make the claim. The latest Week 13 NFL odds have Shedeur Sanders and the Browns as 5.5-point home underdogs to a 49ers team coming off a short week and one that has failed to cover in its last five games versus AFC opponents. Cleveland isn't alone in being a home dog as there are six of them across the 12-game slate on Sunday and Monday.

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Other contests with home underdogs, per the Week 13 NFL spreads, include Jaguars vs. Titans (+6), Falcons vs. Jets (+2.5), Bills vs. Steelers (+3), as Aaron Rodgers (wrist) returns to play, and Broncos vs. Commanders (+6.5) on 'SNF' as Jayden Daniels (elbow) has been ruled out, while Bo Nix and Denver aim for their ninth straight win.

Before locking in any NFL bets, make sure you see what SportsLine's advanced computer model has to say. 

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 13 on a 49-33 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!

Now, the model has evaluated the latest NFL odds, simulated every snap for Week 13 of the 2025 NFL season, and the results are in.

We can tell you one of the model's strongest Week 13 NFL picks is that the Falcons (-2.5, 39.5) cover at the New York Jets in a Sunday 1 p.m. ET kickoff. The model has Atlanta prevailing versus the spread well over 50% of the time. Another one of its Week 13 NFL predictions: the Jaguars (-6.5, 41.5) cover versus the Titans in well over 50% of simulations. The model also says the Over hits in almost 60% of simulations.

The model has also made the call on who wins and covers in every other NFL game this week and just revealed FOUR teams projected to outright win in 70% of simulations, or more! You ABSOLUTELY NEED to see its NFL picks for every game before you make any NFL bets of your own!

So which NFL teams should you back in Week 13, and which four teams should you lock in RIGHT NOW? ... Join SportsLine now to see who wins and covers every single NFL game this week, all from the model on 49-33 roll on top-rated NFL picks!

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