NFL odds, lines, spreads: 2025 Week 12 picks, predictions from proven model: 5-way parlay pays almost 25-1

A number of games with playoff implications highlight the 14-game NFL Week 12 schedule. Among them is an NFC North battle between the Minnesota Vikings (4-6) and Green Bay Packers (6-3-1) at Lambeau Field in Green Bay. Minnesota won both matchups a year ago against the Packers, who will be without running back Josh Jacobs (knee). The Packers are 6.5-favorites, but are just 3-7 against the spread, while Minnesota is 4-6 ATS. Another huge matchup has the AFC-leading Indianapolis Colts (8-2) traveling to Kansas City to face the 5-5 Chiefs, who have lost two in a row. Kansas City is the 3.5-point favorite and is 5-5 ATS, while the Colts are 6-3-1 ATS. Neither team has covered in each of their last two games.

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There are a number of other intriguing matchups on the Week 12 NFL schedule, including Steelers vs. Bears (-2.5), with Aaron Rodgers (wrist) out and Mason Rudolph getting the start, Eagles (-3) vs. Cowboys, Buccaneers vs. Rams (-7) on Sunday Night Football and Panthers vs. 49ers (-7) on Monday Night Football.

Before locking in any NFL bets, make sure you see what SportsLine's advanced computer model has to say. 

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 12 on a 48-33 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!

The model has scoured the Week 12 NFL odds and locked in five confident NFL best bets. If you successfully parlay its sports betting picks, you'd be looking at a massive payout of around 24-1. 

One pick we'll give away: The model is backing the Seahawks (-13.5, 40.5) to cover against the Titans well over 50% of the time.

The model is also backing a surprising underdog that it says will cover in a tight matchup! You ABSOLUTELY NEED to see its NFL picks for every game before you make any NFL bets of your own!

So which NFL teams should you back in Week 12, and which five picks should you lock in RIGHT NOW? ... Join SportsLine now to see who wins and covers every single NFL game this week, all from the model on a 47-29 roll on top-rated NFL picks!

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