NFL odds, lines, spreads: 2025 Week 10 picks, predictions from proven model: 5-way parlay pays almost 25-1

Teams eyeing division titles clash when the New England Patriots battle the Tampa Bay Buccaneers on Sunday to highlight the NFL Week 10 schedule. The Patriots (7-2) are looking to win their seventh game in a row as they eye their first AFC East title in six years, while the Buccaneers (6-2) have won three of four and are aiming for their fifth consecutive NFC South crown. The Buccaneers enter as 2.5-point favorites, but the Patriots have won seven of 10 all-time meetings, including four of the last five. This is one of four Week 10 matchups with a spread of 2.5 or fewer.

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There are a number of other intriguing matchups on the Week 10 NFL schedule, including a matchup where teams recently welcomed back their starting quarterbacks in Ravens at Vikings (+4.5), plus Steelers at Chargers (-3.5), Jaguars at Texans (+1.5) and Eagles at Packers (-1.5) on Monday, as Green Bay looks to overcome the loss of explosive tight end Tucker Kraft (knee).

Before locking in any NFL bets, make sure you see what SportsLine's advanced computer model has to say. 

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a sizzling 47-29 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!

The model has scoured the Week 10 NFL odds and locked in five confident NFL best bets. If you successfully parlay its sports betting picks, you'd be looking at a massive payout of around 24-1. 

One pick we'll give away: The model is backing the Bills (-9.5) to cover against the Dolphins 60% of the time.

The model is also backing a surprising underdog that it says will cover in a tight matchup! You ABSOLUTELY NEED to see its NFL picks for every game before you make any NFL bets of your own!

So which NFL teams should you back in Week 10, and which five picks should you lock in RIGHT NOW? ... Join SportsLine now to see who wins and covers every single NFL game this week, all from the model on a 47-29 roll on top-rated NFL picks!

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