The Washington Commanders look to build on last year's success when they open the 2025 NFL regular season against the NFC East-rival New York Giants on Sunday, Sept. 7. The model is high on the Commanders (-6.5, 45.5) to cover against the Giants. Washington reached the NFC Championship Game last season. The Commanders had won seven consecutive games going into that game behind Jayden Daniels, now in his second season. 

Daniels was dominant in 2024, completing 69% of his passes for 3,568 yards, 25 touchdowns, with just nine interceptions. The Commanders won both meetings last season, and the model has them covering in 60% of simulations. Other divisional matchups on the Week 1 NFL schedule include Bengals vs. Browns (+5.5), Packers vs. Lions (+1.5) and 49ers vs. Seahawks (+1.5). Which other teams have value to include in Week 1 NFL parlay bets, and which side of the NFL odds should you target?

Before you lock in any NFL bets, make sure you see what SportsLine's advanced computer model has to say. 

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model went 31-15 on top-rated picks in 2024. Anybody following could have seen HUGE returns!

The model has scoured the Week 1 NFL odds and locked in five confident NFL best bets. If you successfully parlay its sports betting picks, you'd be looking at a massive payout of around 25-1. 

One pick we'll give away: The model is backing the Commanders (-6.5) to cover against the Giants more than 60% of the time.

The model is also backing a surprising underdog that it says will not only cover, but win outright! You ABSOLUTELY NEED to see its NFL picks for every game before you make any NFL bets of your own!

So which NFL teams should you back in Week 1, and which five picks should you lock in RIGHT NOW? ... Join SportsLine now to see who wins and covers every single NFL game this week, all from the model on a 31-15 roll on top-rated NFL picks!