NFL DFS, Week 10: Chargers vs. 49ers optimal FanDuel, DraftKings lineups for Sunday Night from a daily Fantasy pro

San Francisco 49ers receiver Deebo Samuel is set to make his return to action on Sunday night against the Los Angeles Chargers after missing Week 8 with a pulled hamstring. Meanwhile, Chargers wide receivers Keenan Allen (hamstring) and Mike Williams (ankle) may have to spend another week out of NFL DFS lineups due to injury. What pass-catchers in the NFL DFS player pool can you target if they're not able to give it a go on Sunday night? Before you make your NFL DFS picks, you NEED to see what SportsLine daily Fantasy expert Mike McClure has to say.

McClure is a legendary professional DFS player with over $2 million in career winnings. His methodology has led to enormous cashes on FanDuel and DraftKings. He took down two high-stakes tournaments on FanDuel in 2020 and recorded a pair of top-10 finishes in tournaments with over 130,000 entrants on DraftKings. His lineups also finished inside the top 1% in more than a dozen other tournaments.

He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends and injuries into account. This allows him to find the best DFS values that he shares only with members at SportsLine.

This year, he's already won the DraftKings Millionaire Maker twice and the FanDuel Million once! Now, McClure has turned his attention to Chargers vs. 49ers and locked in his top daily Fantasy football picks.

We can tell you that 49ers running back Christian McCaffrey is one of McClure's top NFL DFS picks for Sunday Night Football. Part of McClure's optimal NFL DFS strategy also includes Chargers running back Austin Ekeler. With the Chargers' top two receivers still on the mend, the Chargers should focus on their ground attack with Ekeler. Last week against the Falcons, he finished with 47 yards and a touchdown, and he scored again on a goal line reception in Los Angeles' 20-17 win.

McClure is also targeting a player who could go off for MASSIVE numbers on Sunday Night Football! This pick could be the difference between winning your tournaments and cash games or going home with nothing! You ABSOLUTELY need to see who it is before locking in any lineups.

What are the top NFL DFS picks for Chargers vs. 49ers on Thursday Night Football? And which player is a MUST-ROSTER? ... Join SportsLine now to see DFS pro Mike McClure's top picks, stacks, and player pools for FanDuel and DraftKings, and cash in BIG on NFL DFS!