The Week 15 NFL schedule opens with a NFC West rivalry game as Geno Smith and the Seattle Seahawks host Brock Purdy, Christian McCaffrey, and the San Francisco 49ers at Lumen Field on Thursday Night Football. The 49ers have won six straight games and beat the Seahawks 27-7 in Week 2. San Francisco will be without dynamic wide receiver Deebo Samuel (ankle), while the Seahawks are looking to bounce back from a disappointing 30-24 loss to the Carolina Panthers in Week 14. Before locking in any Seahawks vs. 49ers Showdown NFL DFS lineups for Thursday Night Football on sites like DraftKings and FanDuel, you NEED to see what SportsLine's Jimmie Kaylor has to say.

Kaylor is a NFL and DFS expert for SportsLine, who opened the 2022 NFL season by winning DraftKings' NFL Showdown Thursday Kickoff Millionaire contest. He edged out over 355,000 other entrants in the contest and also has multiple five-figure tournament wins on his DFS resume. Kaylor, who has been cashing big all season, has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America, and his background as a former college and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks.  

Kaylor has been spot-on all season, hitting on epic NFL DFS picks like Jerry Jeudy (4-102-1), Stefon Diggs (12-148-3, 6-106-1, 7-92-1), Amari Cooper (7-101-1, 5-131-1), Nick Chubb (23-113-1, 23-101-2), CeeDee Lamb (8-87-1), Deebo Samuel (6-115-1) Cooper Kupp (14-122), Travis Kelce (7-25-4, 10-106), Davante Adams (3-124-2), Justin Fields (179-1-1, 82-1), Derrick Henry (132-2), Jimmy Garoppolo (228-4), and Michael Pittman (7-61-1). Anyone who has followed his picks is WAY UP!

Now, Kaylor has turned his attention to 49ers vs. Seahawks on Week 15 Thursday Night Football and locked in his top daily Fantasy football picks.

We can tell you that one of Kaylor's top NFL DFS picks for the Seahawks vs. 49ers TNF matchup is San Francisco running back Christian McCaffrey. "Christian McCaffrey is a must-start player in most Showdown slates on both FanDuel and DraftKings, but I am particularly high on him in Week 15 against the Seahawks. San Francisco will be without wide receiver Deebo Samuel, which alone should open up a few more touches for McCaffrey. Couple that with Seattle ranking second to last in the league rushing yards allowed per game (160.5) and you have the makings of a monster NFL DFS performance for McCaffrey on TNF. I am projecting around 20 touches for 125-plus total yards and a touchdown for McCaffrey on Thursday night."

Kaylor is also targeting another under-the-radar option for TNF who could post HUGE numbers and carry your lineups to victory on Thursday Night Football. This pick could be the difference between winning your tournaments and cash games or going home with nothing! You ABSOLUTELY need to see who it is before locking in any lineups.

Be sure to follow Jimmie (@jimmiekaylor) on Twitter for notifications about rosters changes/updates.

What are the top NFL DFS picks for 49ers vs. Seahawks on FanDuel and DraftKings? And which player is a MUST-ROSTER? ... Join SportsLine now to see NFL expert and DraftKings Millionaire winner Jimmie Kaylor's top picks, stacks, and player pools for FanDuel and DraftKings, and cash in BIG on NFL DFS!