The Week 5 NFL schedule opens with a prime time matchup between the Los Angeles Rams and San Francisco 49ers on Thursday Night Football. Kickoff at SoFi Stadium in Inglewood is at 8:15 p.m. ET. Big-name players such as Christian McCaffrey, Matthew Stafford, Kyren Williams, and Puka Nacua will headline the NFL DFS player pool, but history has proven that finding value in the lesser known players is a key to building successful Showdown NFL DFS lineups. Missing from the NFL DFS player pool will be injured 49ers Brock Purdy, Jauan Jennings and Ricky Pearsall, which potentially gives value to underrated names like Jake Tonges, Kendrick Bourne and Demarcus Robinson.

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Before locking in any NFL DFS lineups or stacks for Rams vs. 49ers on Thursday Night Football on sites like DraftKings and FanDuel, you NEED to see what SportsLine's Jimmie Kaylor has to say.

Kaylor is a NFL and DFS expert for SportsLine, who opened the 2022 NFL season by winning DraftKings' NFL Showdown Thursday Kickoff Millionaire contest. He edged out over 355,000 other entrants in the contest and also has multiple five-figure tournament wins on his DFS resume. Kaylor has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America, and his background as a former college and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. 

Now, Kaylor has turned his attention to 49ers vs. Rams on Thursday Night Football and locked in his top daily Fantasy football picks.

We can tell you that one of Kaylor's top NFL DFS picks for Rams vs. 49ers is San Francisco running back Christian McCaffrey. He's also rostering Rams wide receiver Puka Nacua.

Kaylor is also targeting another under-the-radar player who could post HUGE numbers and carry your lineups to victory! His NFL DFS picks could be the difference between winning your tournaments and cash games or going home with nothing! You ABSOLUTELY need to see who it is before locking in any lineups!

What are the top NFL DFS picks for 49ers vs. Rams on Thursday Night Football, and which unheralded player is a MUST-ROSTER? ... Join SportsLine now to see NFL expert and DraftKings Millionaire winner Jimmie Kaylor's top picks, stacks, and player pools for FanDuel and DraftKings, all from a proven DFS expert who won a Millionaire Maker tournament!

Be sure to follow Jimmie (@jimmiekaylor) on Twitter for notifications about rosters changes/updates