The Week 1 NFL schedule kicks off with the 2025 NFL Kickoff Game between the defending Super Bowl champion Philadelphia Eagles and the Dallas Cowboys on Thursday, September 4. Kickoff in the NFC North rivalry game at Lincoln Financial Field is at 8:20 p.m. ET. The Eagles are favored by 8 points and the Over/Under is 48 points in the latest Cowboys vs. Eagles odds. Perennial Pro Bowl-caliber players like Jalen Hurts, Saquon Barkley, A.J. Brown, CeeDee Lamb, and Dak Prescott headline the NFL DFS player pool, but history has proven that finding value in the lesser known players is a key to building successful Showdown NFL DFS lineups. Should any of Dallas Goedert, Jaydon Blue or Jalen Tolbert find their way into your daily Fantasy football lineups?

Before locking in any playoff NFL DFS lineups or daily Fantasy football stacks for Cowboys vs. Eagles in the 2025 NFL Kickoff Game on sites like DraftKings and FanDuel, you NEED to see what SportsLine's Jimmie Kaylor has to say.

Kaylor is a NFL and DFS expert for SportsLine, who opened the 2022 NFL season by winning DraftKings' NFL Showdown Thursday Kickoff Millionaire contest. He edged out over 355,000 other entrants in the contest and also has multiple five-figure tournament wins on his DFS resume. Kaylor has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America, and his background as a former college and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. 

Now, Kaylor has turned his attention to Cowboys vs. Eagles in the 2025 NFL Kickoff Game and locked in his top daily Fantasy football picks.

We can tell you that one of Kaylor's top NFL DFS picks for Eagles vs. Cowboys is Eagles quarterback Jalen Hurts. He's also rostering Eagles running back Saquon Barkley. The Eagles were dominant against the Cowboys in 2024, and Hurts and Barkley give Philadelphia a dominant red zone duo. That duo will face a Dallas team which ranked in the bottom four in rushing yards allowed, yards per carry allowed and rushing touchdowns given up in 2024.

Kaylor is also targeting another under-the-radar player who could post HUGE numbers and carry your lineups to victory! His NFL DFS picks could be the difference between winning your tournaments and cash games or going home with nothing! You ABSOLUTELY need to see who it is before locking in any lineups!

What are the top NFL DFS picks for Eagles vs. Cowboys in the 2025 NFL Kickoff Game, and which unheralded player is a MUST-ROSTER? ... Join SportsLine now to see NFL expert and DraftKings Millionaire winner Jimmie Kaylor's top picks, stacks, and player pools for FanDuel and DraftKings, all from a proven DFS expert who won a Millionaire Maker tournament!

Be sure to follow Jimmie (@jimmiekaylor) on Twitter/X for notifications about rosters changes/updates