NFL DFS Monday Night Football picks, Week 4: Rams vs. 49ers fantasy lineup advice for DraftKings, Fanduel from Millionaire contest winner

The 2022 Week 4 NFL schedule closes out with an NFC West rivalry game between Jimmy Garoppolo and the San Francisco 49ers and Matthew Stafford and the Los Angeles Rams on Monday Night Football. Garoppolo will be making his second start for San Francisco after taking over for Trey Lance. For the Rams, Cooper Kupp and Aaron Donald continue to be arguably the top players in the NFL at their respective positions. Before locking in any Showdown NFL DFS lineups for Monday Night Football on sites like DraftKings and FanDuel, you NEED to see what SportsLine's Jimmie Kaylor has to say.

Kaylor is a NFL and DFS expert for SportsLine, who opened the 2022 NFL season by winning DraftKings' NFL Showdown Thursday Kickoff Millionaire contest! He edged out over 355,000 other entrants in the contest and also has multiple five-figure tournament wins on his DFS resume. Kaylor has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America, and his background as a former college and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks.  

In Week 1 Monday Night Football, Kaylor listed Denver wide receiver Jerry Jeudy as one of his top Showdown DFS picks and the former Alabama star was the highest scoring fantasy player in the game. In Week 2 MNF, Kaylor called for a huge night from Buffalo wide receiver Stefon Diggs and he delivered 12 receptions for 148 yards and three touchdowns. In Week 3 TNF, Kaylor dominated with the Cleveland duo of Amari Cooper and Nick Chubb. Last week, he was all over Dallas wide receiver CeeDee Lamb, who was the highest scorer in the game.

Now, Kaylor has turned his attention to the MNF matchup of 49ers vs. Rams and locked in his top daily Fantasy football picks.

We can tell you that one of Kaylor's top NFL DFS picks for Monday is San Francisco wide receiver Deebo Samuel. "He has yet to have a huge game by his standards in 2022, and I think this is the week we see it happen. Samuel has given the Rams fits in the past, catching 13 passes for 264 yards and two touchdowns and rushing for 107 yards and two touchdowns in three matchups last season. If this game goes as I expect it to, the 49ers will be playing from behind, giving Samuel plenty of opportunity to rack up catches and yards in the second half. I'm expecting double-digit targets and upwards of 15 total touches for Samuel on Monday night."

Kaylor is also targeting another under-the-radar player for MNF who could post HUGE numbers and carry your lineups to victory! His DFS picks could be the difference between winning your tournaments and cash games or going home with nothing! You ABSOLUTELY need to see who it is before locking in any lineups.

What are the top NFL DFS picks for the MNF matchup of Rams vs. 49ers on FanDuel and DraftKings? And which player is a MUST-ROSTER? ... Join SportsLine now to see NFL expert and DraftKings Millionaire winner Jimmie Kaylor's top picks, stacks, and player pools for FanDuel and DraftKings, all from a DFS expert who already won a millionaire maker tournament in 2022!