NFL DFS Monday Night Football picks, Week 11: 49ers vs. Cardinals fantasy lineup advice for DraftKings, Fanduel from Millionaire contest winner

The 2022 Week 11 NFL schedule closes out with a NFC West rivalry game between the Arizona Cardinals and San Francisco 49ers on Monday Night Football at Estadio Azteca in Mexico City. The 49ers, led by Jimmy Garoppolo, Christian McCaffrey, George Kittle, and Deebo Samuel, are looking to extend their winning streak to three games, while the Cardinals are hoping to build off their 27-17 win over the Los Angeles Rams in Week 10. Before locking in any NFL DFS lineups for Monday Night Football on sites like DraftKings and FanDuel, you NEED to see what SportsLine's Jimmie Kaylor has to say.

Kaylor is a NFL and DFS expert for SportsLine, who opened the 2022 NFL season by winning DraftKings' NFL Showdown Thursday Kickoff Millionaire contest. He edged out over 355,000 other entrants in the contest and also has multiple five-figure tournament wins on his DFS resume. Kaylor, who has been cashing big all season, has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America, and his background as a former college and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks.  

Kaylor has been spot-on all season, hitting on epic NFL DFS picks in primetime showdown matchups like Jerry Jeudy (4-102-1), Stefon Diggs (12-148-3), Amari Cooper (7-101-1), Nick Chubb (23-113-1), CeeDee Lamb (8-87-1), Deebo Samuel (6-115-1) Cooper Kupp (14-122), Travis Kelce (7-25-4), Davante Adams (3-124-2), Justin Fields (179-1-1, 82-1), Diggs again in Week 8 (6-106-1), Chubb (23-101-2) and Cooper (5-131-1) again on MNF in Week 8, Kelce again on Week 9 SNF (10-106), and Derrick Henry (132 total yards, 2 TDs) on Week 11 TNF. Anyone who has followed his picks is WAY UP!

Now, Kaylor has turned his attention to the Week 11 MNF matchup of Cardinals vs. 49ers in Mexico City and locked in his top daily Fantasy football picks.

We can tell you that one of Kaylor's top NFL DFS picks for Monday Night Football is Philadelphia wide receiver Deebo Samuel. "Deebo Samuel's role in the 49ers offense seems to have diminished slightly since the arrival of Christian McCaffrey, but this is the week I think he explodes for one of his best games of the season. The Cardinals are beat up on both sides of the ball, and I am expecting them to commit to slowing down McCaffrey, which should open things up for Samuel to record multiple explosive plays and wow the international crowd at Estadio Azteca in Mexico City. I am projecting over 100 total yards and a touchdown for Samuel on MNF."

Kaylor is also targeting another under-the-radar player for MNF who could post HUGE numbers and carry your lineups to victory! His NFL DFS picks could be the difference between winning your tournaments and cash games or going home with nothing! You ABSOLUTELY need to see who it is before locking in any lineups.

Be sure to follow Jimmie (@jimmiekaylor) on Twitter for notifications about rosters changes/updates

What are the top NFL DFS picks for the MNF matchup of 49ers vs. Cardinals on FanDuel and DraftKings? And which player is a MUST-ROSTER? ... Join SportsLine now to see NFL expert and DraftKings Millionaire winner Jimmie Kaylor's top picks, stacks, and player pools for FanDuel and DraftKings, all from a DFS expert who already won a Millionaire Maker tournament in 2022!