Nebraska vs. Indiana odds, line, spread: Proven model reveals college football picks, predictions for Week 5, 2022

A Big Ten battle is on tap between the Nebraska Cornhuskers and the Indiana Hoosiers at 7:30 p.m. ET on Saturday at Tom Osborne Field at Memorial Stadium in Lincoln, NE. Nebraska is 1-3 overall and 1-2 at home, while IU is 3-1 overall and 0-1 on the road. The Hoosiers are coming off a 45-24 road loss to Cincinnati while Nebraska enters play off a bye week following a 49-14 blowout home loss to then No. 6 ranked Oklahoma. The Cornhuskers are favored by 5.5 points in the latest Nebraska vs. Indiana odds from Caesars Sportsbook, and the over/under is set at 60. 

Before you make any Indiana vs. Nebraska picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of more than $3,100 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen HUGE returns!

Now, it has simulated Nebraska vs. Indiana 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in over 50% of simulations. You absolutely need to see it before locking in your own picks.

So who wins Nebraska vs. Indiana? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks.