NBA odds, lines, spreads, picks, predictions for Wednesday, October 22: 3-way parlay pays well over 5-1

The 2025-26 NBA schedule rolls on with a 12-game slate on Wednesday, Oct. 22. Among the most notable matchups of the slate are Cavaliers vs. Knicks at 7 p.m. ET, 76ers vs. Celtics at 7:30 p.m. ET, and Spurs vs. Mavericks in the NBA debut of Cooper Flagg at 9:30 p.m. ET. 

LIMITED TIME: Use promo code CHAMPIONSHIP to get your first month for $1 JOIN NOW.

Before locking in any NBA bets or parlays, make sure you see what SportsLine's advanced computer model has to say. 

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past seven seasons. The model enters the 2025-26 NBA season on a sizzling 160-118 roll on all top-rated NBA picks, returning nearly $4,000. It also went 24-11 (69%) on top-rated NBA against-the-spread picks last season. Anyone following its NBA betting advice at sportsbooks and on betting apps could have seen huge returns. Anybody following could have seen HUGE returns!

The model has scoured the Wednesday NBA odds locked in five confident NBA best bets. If you successfully parlay them you'd be looking at a massive payout of well over +500.

One pick we'll give away: The model is backing the Dallas Mavericks (-2.5) to cover against the San Antonio Spurs in their game at 9:30 p.m. ET.

The model has also locked in spread picks for both matchups, including an A-rated spread pick that hits almost 70% of the time! You ABSOLUTELY need to see it right now.

So what are the NBA best bets for Wednesday? ... Join SportsLine now to see who wins and covers every single NBA game this week, all from the model that's up more than $4k on top-rated NBA picks!

LIMITED TIME: Use promo code CHAMPIONSHIP to get your first month for $1 JOIN NOW.