N.C. State vs. Louisville odds, prediction: 2026 Atlantic Coast Conference men's college basketball picks from proven model

Teams looking to stay within shouting distance of the top spot in the Atlantic Coast Conference battle when the North Carolina State Wolfpack clash with the 24th-ranked Louisville Cardinals on Monday night. N.C. State is coming off an 82-73 win over Virginia Tech on Saturday, while Louisville downed Wake Forest 88-80 that same day. The Wolfpack (18-6, 9-2 ACC), Who are tied for third in the conference with Virginia, have won six in a row and are 6-1 on the road this season. The Cardinals (17-6, 7-4 ACC), who are seventh in the league, has won three in a row and is 12-2 on their home floor.

Tip-off from KFC Yum! Center in Louisville, Ky., is set for 7 p.m. ET. Louisville leads the all-time series 15-14, including a 7-4 edge in games played in Louisville. Louisville is a 6.5-point favorite in the latest N.C. State vs. Louisville odds from DraftKings Sportsbook, while the over/under for total points scored is 161.5. 

Before making any N.C. State vs. Louisville picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and it enters Week 14 on a sizzling 10-1 run on its top-rated over/under college basketball picks dating back to last season, and is on an 8-1 run on top-rated CBB side picks. Anyone following its college basketball betting advice at sportsbooks and on betting apps could have seen strong returns.

The model has simulated N.C. State vs. Louisville 10,000 times and the results are in. The model is leaning Under, and it also says one side of the spread hits over 50% of the time!

So who wins N.C. State vs. Louisville, and which side of the spread hits over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!