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Monday Night Football Rams vs. 49ers game line, odds: Proven model reveals NFL picks, predictions for MNF

The SportsLine Projection Model has simulated Rams vs. 49ers 10,000 times and revealed its Week 10 NFL picks
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NFC West rivals will meet up on Monday Night Football when the Los Angeles Rams (7-2) visit the San Francisco 49ers (3-5). The Rams' four-game-win streak was snapped last week, as Los Angeles is coming off a disappointing 28-16 loss to the Tennessee Titans. The 49ers lost 31-17 to the Arizona Cardinals and dropped to 0-3 in division play. 

Kickoff from Levi's Stadium is set for 8:15 p.m. ET. The Rams are favored by 3.5 points in the latest Rams vs. 49ers odds from Caesars Sportsbook, while the Over-Under is 50.5. Before making you make any Rams vs. 49ers picks, you NEED to check out the latest NFL predictions from the SportsLine Projection Model. 

The model, which simulates every NFL game 10,000 times, is up almost $7,600 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 10 of the 2021 season on an incredible 128-88 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP!

The model knows Rams' quarterback Matthew Stafford is first in the NFL in passing yards (2,771) and second in passing touchdowns (23). Stafford has tossed at least two passing touchdowns in seven games thus far. The Georgia product also leads the NFL in QBR (69.7).

The model also knows 49ers quarterback Jimmy Garoppolo is coming off back-to-back 300-yard games. He has completed 65 percent of his passes for 1,754 yards with eight touchdowns. 

Now, the model has set its sights on Rams vs. 49ers on Monday Night Football. We can tell you it's leaning Under the total, and it also says one side of the spread hits in over 50 percent of simulations! You ABSOLUTELY need to see it before locking in any Rams vs. 49ers picks of your own.

So who wins 49ers vs. Rams on Monday Night Football? And which side of the spread hits in over 50 percent of simulations? ... Join SportsLine right now to see which side of the Rams vs. 49ers spread to back, all from the dialed-in NFL model that's up almost $7,600 on top-rated picks!

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SportsLine Staff