MLB odds, lines, April 11, 2022 picks: Parlay for Monday's games that would pay over 10-1 from proven computer model

The opening weekend of the MLB season is in books, but several teams will wrap up their four-game series on Monday. Seattle won its first two games at Minnesota before coming up short on Sunday night. The Mariners will try to win the series at 7:40 p.m. ET on Monday, as they look to snap the longest playoff drought of any North American sports team this season. Elsewhere, National League West rivals San Francisco and San Diego will do battle in the first game of their series after they each picked up a series win to open the year. 

Right-handed pitcher Nick Martinez will be on the mound for San Diego, while left-hander Alex Wood is going to start for San Francisco. The Giants are priced as -150 favorites in the latest MLB odds at Caesars Sportsbook. Tampa Bay will look to remain unbeaten when it takes on Oakland as a -230 favorite at 6:40 p.m. ET. (See up-to-date lines for every game on our MLB odds page.)

Before making any MLB picks or parlays, be sure to see the MLB predictions and betting advice from SportsLine's proven computer model.

This model, which simulates every game 10,000 times, enters Week 2 of the 2022 season on a 216-181 roll on top-rated MLB money-line picks that dates back to last season, returning over $900 for $100 players. Anyone following it has seen HUGE returns!

Now, the model has set its sights on the MLB schedule for Monday. Using its top picks for the day, the model has generated a four-leg parlay that would pay more than 10-1! The parlay doesn't start until 7:20 p.m. ET, giving you plenty of time to make your MLB picks!

We can tell you that one of the picks is the Braves vs. Nationals matchup to go Over 9.5 runs (+100). But the model has three other picks, including a play on a road underdog that is winning in well over 50 percent of simulations! You ABSOLUTELY need to see them before locking in any MLB picks of your own.

So which road underdog is a MUST-BACK? And what other teams do you need to include in your parlay for a payout of more than 10-1? ... Join SportsLine right now to find out which picks you should be all over on Monday, all from the model that has gone 216-181 dating back to last season!