Two major contenders to win the American League collide when the Baltimore Orioles and Houston Astros begin a three-game series on Tuesday at Oriole Park at Camden Yards in Baltimore. The Orioles (70-42) have the best record in the AL and second best record in baseball. Meanwhile the defending World Series champion Astros (64-49) have the second best record in the AL West. 

Houston is a -130 favorite in the latest Astros vs. Orioles odds, while Baltimore is a +110 underdog. The over/under for runs scored is 8.5. The game is one of 16 on the MLB schedule for Tuesday. (See up-to-date lines for every game on our MLB odds page.)

Before making any MLB picks or parlays, be sure to see the predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times. It went 331-285 on top-rated MLB money-line picks (+357) over the past two seasons. It entered Week 20 of the 2023 MLB season 54-43 on all top-rated MLB picks this season and has excelled on top-rated run-line picks, going 11-4 (+404). Anybody following it has seen big returns.

Now, the model has set its sights on the MLB schedule for Tuesday and has generated a three-leg parlay that would pay more than 8-1! The parlay doesn't start until 6:40 p.m. ET, giving you plenty of time to make your MLB picks.

We can tell you that one of the top picks is the Cincinnati Reds (+114) to beat the Miami Marlins. The model has two other confident picks, including a play on an even bigger National League underdog! You ABSOLUTELY need to see them before locking in any MLB picks of your own.

So which National League underdog is a MUST-BACK? And what other teams do you need to include in your parlay for a payout of more than 8-1? ... Join SportsLine right now to find out which picks you should be all over on Tuesday, all from the model that is 54-43 on top-rated picks this season!