Two American League teams with postseason hopes collide when the Cleveland Guardians and Seattle Mariners begin a key four-game series on Thursday at T-Mobile Park in Seattle. The Guardians (66-56) lead the AL Central by four games over the Twins and White Sox. Meanwhile the Mariners (67-57) own the third and last wild card spot in the AL. 

Cleveland is a -115 favorite in the latest Guardians vs. Mariners odds from Caesars Sportsbook while Seattle is a -105 underdog. First pitch is set for 4:10 p.m. ET. The game is one of nine on the MLB schedule for Thursday. (See up-to-date lines for every game on our MLB odds page.)

Before making any MLB picks or parlays, be sure to see the predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it is a 305-263 on top-rated MLB money-line picks since the start of the 2021 season. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win the World Series. Anybody who has followed the model has seen profitable returns.

Now, the model has set its sights on the MLB schedule for Thursday, Aug. 25 and has generated a three-leg parlay that would pay more than 13-1! The parlay doesn't start until 7:05 p.m. ET, giving you plenty of time to make your MLB picks.

We can tell you that one of the picks is the Red Sox (+143) to beat the Blue Jays. But the model has two other picks, including a play on an enormous underdog! You ABSOLUTELY need to see them before locking in any MLB picks of your own.

So which underdog is a MUST-BACK? And what other teams do you need to include in your parlay for a payout of more than 13-1? ... Join SportsLine right now to find out which picks you should be all over on Thursday, all from the model that is on a 305-263 run on top-rated MLB money-line picks since the start of 2021!