The reigning World Series champion Houston Astros can clinch their seventh straight trip to the American League Championship Series when they face the Minnesota Twins in Game 4 of their AL Division Series at Target Field in Minneapolis. The Astros own a 2-1 lead in the best-of-five series and, with a win on Wednesday, would inch closer to the Braves' MLB record of eight straight league championship series appearances.

Minnesota is a -122 (risk $122 to win $100) favorite in the latest Twins vs. Astros odds, while Houston is a +103 underdog. The over/under for runs scored is 8. First pitch is scheduled for 7:07 p.m. ET. The game is one of three Division Series games on the MLB schedule for Wednesday. 

Before making any MLB Division Series picks or parlays, be sure to see the predictions and betting advice from SportsLine's proven computer model. (See up-to-date lines for every game on our MLB odds page.)

The SportsLine Projection Model simulates every MLB game 10,000 times. It went 331-285 on top-rated MLB money-line picks (+357) over the past two seasons. It entered the second week of the 2023 MLB playoffs 92-74 on all top-rated MLB picks this season and has excelled on top-rated run-line picks, going 18-6 (+766). Anybody following has seen big returns.

Now, the model has set its sights on the MLB Division Series schedule for Wednesday and has generated a three-leg parlay that would pay more than 6-1. The parlay starts at 5:07 p.m. ET, giving you plenty of time to make your MLB picks.

We can tell you that one of the picks is the Astros to beat the Twins. But the model has two other picks, including one that would pay plus-money. You ABSOLUTELY need to see them before locking in any MLB picks of your own.

So what other picks do you need to include in your parlay for a payout of 6-1? And what plus-money wager is a must-back? ... Join SportsLine right now to find out which picks you should be all over on Wednesday, all from the model that is 92-74 on all top-rated MLB picks this season.