The Baltimore Orioles will try to bounce back from a stunning loss when they host the Houston Astros on Wednesday in the middle game of a three-game series at Oriole Park at Camden Yards in Baltimore. In the series opener between the two American League heavyweights on Tuesday, lights-out Orioles closer Felix Bautista gave up a grand slam to Kyle Tucker in the ninth inning, which propelled the Astros to a 7-6 victory. 

Baltimore is a -122 favorite in the latest Orioles vs. Astros odds, while Houston is a +103 underdog. The over/under for runs scored is 9.5. The game is one of 15 on the MLB schedule for Wednesday. (See up-to-date lines for every game on our MLB odds page.)

Before making any MLB picks or parlays, be sure to see the predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times. It went 331-285 on top-rated MLB money-line picks (+357) over the past two seasons. It entered Week 20 of the 2023 MLB season 54-43 on all top-rated MLB picks this season and has excelled on top-rated run-line picks, going 11-4 (+404). Anybody following the model has seen big returns.

Now, the model has set its sights on the MLB schedule for Wednesday and has generated a three-leg parlay that would pay more than 7-1! The parlay doesn't start until 7:05 p.m. ET, giving you plenty of time to make your MLB picks.

We can tell you that one of the picks is the Astros (+103) to beat the Orioles. But the model has two other picks, including a play on an even bigger AL underdog! You ABSOLUTELY need to see them before locking in any MLB picks of your own.

So which AL underdog is a MUST-BACK? And what other teams do you need to include in your parlay for a payout of more than 7-1? ... Join SportsLine right now to find out which picks you should be all over on Wednesday, all from the model that is 54-43 on top-rated picks this season!