MLB odds, lines, picks: Advanced computer model includes Rockies in parlay for April 22 that would pay almost 19-1

The two teams favored to win the American League collide when the Toronto Blue Jays and Houston Astros open a three-game series on Friday at Minute Maid Park in Houston. The Blue Jays (8-5) lead the AL East and are the favorites to win the pennant according to Caesars Sportsbook. The Astros (6-6) are off to a slow start but are still the second choice in the AL. 

On Friday Houston is a -170 moneyline favorite in the latest Astros vs. Blue Jays odds from Caesars Sportsbook, while Toronto is a +150 underdog. First pitch is set for 8:10 p.m. ET. The game is one of 15 on the MLB schedule on Friday. (See up-to-date lines for every game on our MLB odds page.)

Before making any MLB picks or parlays, be sure to see the MLB predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a sizzling start to the 2022 season. It's on a 14-4 roll on top-rated MLB moneyline picks through two weeks, returning more than $800 for $100 players. Anyone following it has seen HUGE returns.

Now, the model has set its sights on the MLB schedule for Friday, April 22. Using its top picks for the day, the model has generated a four-team parlay that would pay almost 19-1! The parlay doesn't start until 7:10 p.m. ET, giving you plenty of time to make your MLB picks!

We can tell you that one of the picks is the Rockies (+120) to beat the Tigers (7:10 p.m. ET). But the model has three other picks, including a play on an even bigger underdog! You ABSOLUTELY need to see them before locking in any MLB picks of your own.

So which underdog is a MUST-BACK? And what other teams do you need to include in your parlay for a payout of almost 19-1? ... Join SportsLine right now to find out which picks you should be all over on Friday, all from the model that is on a 14-4 roll on top-rated MLB moneyline picks through two weeks!