The opening game of an intriguing interleague battle between the New York Mets and Houston Astros is among the highlights of the MLB schedule for Tuesday. The teams entered the league together in 1962 and were National League rivals before the Astros moved to the American League in 2013. Now, both have comfortable leads in their divisions and are among the favorites to win the World Series at Caesars Sportsbook. Houston is +700 to win the title, according to Caesars, trailing only the Dodgers (+420) and Yankees (+450) and just ahead of the Mets (+750). The game is one of 15 on the MLB schedule for Tuesday night, with the Yankees vs. Rays and Braves vs. Giants also among the highlights.       

Houston is a -140 favorite on the money line in the latest Mets vs. Astros odds from Caesars Sportsbook. New York is a +120 underdog, while the Over/Under for runs scored is 9. First pitch is set for 8:10 p.m. ET. With a huge slate of games, there are tons of options for you to cash in on wagers, and if you combine them in a parlay, you can hit big. (See up-to-date lines for every game on our MLB odds page.)

Before you make any MLB picks or parlays, be sure to see the predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a strong start to the 2022 season. It's on a 56-47 roll on top-rated MLB money-line picks through 11 weeks. Anybody who has followed it has seen profitable returns.

Now, the model has set its sights on the MLB schedule for Tuesday, June 21. Using its top picks for the day, the model has generated a four-leg parlay that would pay more than 13-1! The parlay doesn't start until 8:05 p.m. ET, giving you plenty of time to make your MLB picks.

We can tell you that one of the picks is San Diego -140 on the money line in the Diamondbacks vs. Padres matchup at 9:40 p.m. ET! The Padres have taken four of five from Arizona this year, and the model has them winning in 69 percent of simulations. The model has three other picks, including two more CONFIDENT money line plays that would pay plus money! You ABSOLUTELY need to see them before locking in any MLB picks of your own.

So which lines have value and can help you cash in BIG Tuesday night? And which underdogs are MUST-BACKS for a parlay with a payout of more than 13-1? ... Join SportsLine right now to find out which picks you should be all over on Tuesday, all from the model that is on a 56-47 roll on top-rated MLB money-line picks through 11 weeks!