MLB odds, lines, picks: Advanced computer model includes Blue Jays in parlay for April 27 that would pay almost 12-1

Reigning AL MVP Shohei Ohtani takes the mound on Wednesday night when he and the Los Angeles Angels host the Cleveland Guardians at Angel Stadium in Anaheim, Calif. Ohtani (1-2, 4.40 ERA) squares off against Zach Plesac (1-1, 1.53).

Los Angeles is a -210 moneyline favorite in the latest Angels vs. Guardians odds from Caesars Sportsbook, while Cleveland is a +180 underdog. First pitch is set for 9:38 p.m. ET. The game is one of 15 on the MLB schedule on Wednesday. (See up-to-date lines for every game on our MLB odds page.)

Before making any MLB picks or parlays, be sure to see the MLB predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a sizzling start to the 2022 season. It's on a 25-11 roll on top-rated MLB moneyline picks through three weeks, returning almost $1,100 for $100 players. Anyone following it has seen HUGE returns.

Now, the model has set its sights on the MLB schedule for Wednesday, April 27. Using its top picks for the day, the model has generated a four-team parlay that would pay almost 12-1. The parlay doesn't start until 6:40 p.m. ET, giving you plenty of time to make your MLB picks.

We can tell you that one of the picks is the Blue Jays (-140) to beat the Red Sox. But the model has three other picks, including a play on an American League underdog. You ABSOLUTELY need to see them before locking in any MLB picks of your own.

So which AL underdog is a MUST-BACK? And what other teams do you need to include in your parlay for a payout of almost 12-1? ... Join SportsLine right now to find out which picks you should be all over on Wednesday, all from the model that is on a 25-11 roll on top-rated MLB moneyline picks through three weeks!