The delayed 2022 MLB season finally begins on Thursday, with seven games from coast-to-coast. Both of last season's World Series participants, the champion Atlanta Braves and Houston Astros, are scheduled to play. Atlanta hosts the Cincinnati Reds and is a 180 moneyline favorite in the latest Braves vs. Reds odds from Caesars Sportsbook, while Cincinnati is a +160 underdog. First pitch is 8:08 p.m. ET. Meanwhile Houston faces Shohei Ohtani and the Los Angeles Angels. Los Angeles is a -130 favorite in the latest Angels vs. Astros odds, while Houston is a +110 underdog. First pitch is 9:38 p.m. ET. (See up-to-date lines for every game on our MLB odds page.)

Before making any Opening Day picks or MLB parlays, be sure to see the MLB predictions and betting advice from SportsLine's proven computer model.

This model, which simulates every game 10,000 times, enters the 2022 MLB season coming off a 209-178 record on top-rated MLB moneyline picks in 2021, returning more than $700 for $100 players. Anyone following it has seen HUGE returns.

Now, the model has set its sights on the MLB schedule for Opening Day. Using its top picks for the day, the model has generated a four-leg parlay that would pay almost 15-1! The parlay doesn't start until 4 p.m. ET, giving you plenty of time to make your MLB picks!

We can tell you that one of the picks is the Houston Astros (+110) to beat the Los Angeles Angels (9:38 p.m. ET). But the model has three other picks, including a play on an even bigger road underdog! You ABSOLUTELY need to see them before locking in any MLB picks of your own.

So which road underdog is a MUST-BACK? And what other teams do you need to include in your parlay for a payout of almost 15-1? ... Join SportsLine right now to find out which picks you should be all over on Opening Day, all from the model that went went 209-178 on top-rated moneyline picks last season!