Two division leaders in the National League collide when the Chicago Cubs and San Francisco Giants open a four-game series on Thursday at Oracle Park in San Francisco. The Giants are -125 money-line favorites in the latest Giants vs. Cubs odds from William Hill Sportsbook, while the Cubs are +115 underdogs.

The game is one of 12 on Thursday's loaded MLB schedule. (See up-to-date lines for every game on our MLB odds page.)

Before entering any MLB picks or parlays, you NEED to see the latest predictions from the SportsLine Projection Model. 

This model, which simulates every pitch of every game 10,000 times, had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line picks. It is off to a fast start in 2021, going 71-52 on top-rated MLB money-line picks through nine weeks, returning more than $800. Anyone following it has seen HUGE rewards!

Now, the model has set its sights on the MLB schedule for Thursday. Using its top picks for the day, the model has generated an EPIC four-leg parlay that would pay more than 16-1! The best part is that the parlay doesn't start until 8:10 p.m. ET, giving you plenty of time to make your MLB picks!

We can tell you that one of the picks is the Mariners (+143) to beat the Angels at 9:38 p.m. ET. But the model has three other picks, including a National League team pulling off a HUGE upset! You ABSOLUTELY need to see it before locking in any MLB picks of your own.

So which National League underdog is a MUST-BACK? And what other teams do you need include in your parlay for a 16-1 payout? ... Join SportsLine right now to find out which picks you should be all over on Thursday, all from the model that is off to a fast start in 2021!