MLB DFS, 2026: Top FanDuel, DraftKings picks, lineups, advice for Wednesday, May 6 from a daily Fantasy pro

All 30 teams are in action on Wednesday's MLB schedule, but half a dozen of those are afternoon contests. Thus, the main slate for MLB DFS contests isn't quite as loaded with top options for daily Fantasy baseball lineups. Still though, the likes of Aaron Judge and Bobby Witt are available as batters, while Paul Skenes highlights those on the mound and in the MLB DFS player pool. Which combination of players should you target in MLB daily Fantasy?

Before making any MLB DFS picks on sites like DraftKings and FanDuel for this slate, you need to see what Mike McClure has to say.

McClure is a DFS professional with over $2 million in career winnings. He's also a predictive data engineer at SportsLine who uses a powerful prediction model that simulates every minute of every game 10,000 times, taking factors like matchups, statistical trends and injuries into account.

This allows him to find the best MLB DFS values and create optimal lineups that he shares only at SportsLine. They're a must-see for any MLB DFS player.

For Wednesday, one of McClure's top MLB DFS picks is Twins outfielder Byron Buxton ($5,900 on DraftKings, $3,700 on FanDuel). He's also stacking Buxton with outfielder Trevor Larnach ($3,200 on DraftKings, $2,900 on FanDuel), who has career highs in both average (.288) and OPS (.843). The Twins have an ideal matchup on Wednesday in facing Washington SP Miles Mikolas, who has an 8.23 ERA across 27.1 innings.

McClure is also targeting a player who could go off for massive numbers on Wednesday! This pick could be the difference between winning your tournaments and cash games or going home with nothing. You absolutely need to see who it is before locking in any lineups.

What are the top MLB DFS picks for Wednesday? ... Join SportsLine now to see DFS pro Mike McClure's top picks, stacks, and player pools for FanDuel and DraftKings, and cash in BIG on MLB DFS!