MLB DFS, 2026: Top FanDuel, DraftKings picks, lineups, advice for Wednesday, April 15, from a daily Fantasy pro

While every team is in action on Wednesday's MLB schedule, there are three afternoon games which could affect your MLB DFS picks. The main slate, though, is still loaded with high-quality options for your daily Fantasy baseball lineups including Vladimir Guerrero Jr., Yordan Alvarez, Fernando Tatis Jr. and Shohei Ohtani. The two-way star is also on the mound today, as are Dylan Cease and Luis Gil, and all of these names could make it a bit difficult in deciding who to pluck from the MLB DFS player pool.

Before making any MLB DFS picks on sites like DraftKings and FanDuel for this slate, you need to see what Mike McClure has to say.

McClure is a DFS professional with over $2 million in career winnings. He's also a predictive data engineer at SportsLine who uses a powerful prediction model that simulates every minute of every game 10,000 times, taking factors like matchups, statistical trends and injuries into account.

This allows him to find the best MLB DFS values and create optimal lineups that he shares only at SportsLine. They're a must-see for any MLB DFS player.

For Wednesday, one of McClure's top MLB DFS picks is Braves third baseman Austin Riley ($3,700 on DraftKings, $2,800 on FanDuel). He's also stacking Riley with outfielder Mike Yastrzemski ($3,000 on both DraftKings, $2,700 on FanDuel). Atlanta is facing Miami SP Chris Paddack, and Yastrzemski has lit up the RHP to the tune of a .391 average and 1.353 OPS across 23 at-bats.

McClure is also targeting a player who could go off for massive numbers on Wednesday! This pick could be the difference between winning your tournaments and cash games or going home with nothing. You absolutely need to see who it is before locking in any lineups.

What are the top MLB DFS picks for Wednesday? ... Join SportsLine now to see DFS pro Mike McClure's top picks, stacks, and player pools for FanDuel and DraftKings, and cash in BIG on MLB DFS!