Missouri vs. Vanderbilt odds, line: 2025 college football picks for Week 9 predictions from proven model

The No. 15 Missouri Tigers (6-1) square off against the No. 10 Vanderbilt Commodores (6-1) in an SEC showdown on Saturday. Last weekend, Missouri defeated Auburn 23-17 in double overtime. Meanwhile, Vanderbilt knocked off LSU 31-24 on Oct. 18. 

Kickoff from the FirstBank Stadium in Nashville, Tenn., is at 3:30 p.m. ET. The Commodores are 3-point favorites in the latest Missouri vs. Vanderbilt odds, while the over/under for total points scored is 53.5.

Before making any Missouri vs. Vanderbilt picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of over $2,000 for $100 players on its top-rated college spread football picks, and is a profitable 42-30 combined on money-line and over/under picks since the beginning of 2024. Anyone following could have seen impressive returns.

The model has simulated Missouri vs. Vanderbilt 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits in well over 60% of simulations!

So who wins Missouri vs. Vanderbilt, and which side of the spread hits well over 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!