Missouri vs. Auburn prediction, odds, line: Advanced computer college football model reveals picks for Saturday's SEC matchup

The Missouri Tigers will make their first-ever appearance at Jordan-Hare Stadium when they take on the Auburn Tigers in a Southeastern Conference crossover matchup on Saturday in Auburn, Ala. Missouri (2-1) was 3-5 in the SEC-East and 6-7 overall in 2021, while Auburn (2-1) was 3-5 in the SEC-West and 6-7 overall. After losing 40-12 to Kansas State in Week 2, Missouri bounced back for a 34-17 win over Abilene Christian last week. Auburn is coming off a 41-12 loss to Penn State in Week 3.

Kickoff is set for noon ET. Auburn is a 7.5-point favorite in the latest Missouri vs. Auburn odds from Caesars Sportsbook, while the over/under for total points scored is 51. (See up-to-date odds for every game this week on our college football odds page.) 

Before you make any Missouri vs. Auburn picks or college football predictions, you NEED to see the predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of more than $3,300 for $100 players on its top-rated college football picks against the spread. It enters Week 4 of the 2022 college football season on a 51-43 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen HUGE returns!

The model knows junior running back Tank Bigsby has been explosive for Auburn. Bigsby has 38 carries for 237 yards (6.2 average) and three touchdowns. In the season opener against Mercer, Bigsby carried 16 times for 147 yards (9.2 average) and two touchdowns. He added a score against San Jose State a week later.

The model also knows sophomore quarterback Brady Cook has played well in Missouri's two wins, including Saturday against Abilene Christian. In that game, Cook completed 22 of 31 passes (71%) for 297 yards and three touchdowns. For his career, Cook has completed 71.3% of his passes for 1,043 yards and seven touchdowns vs. three interceptions.

Now, the model has set its sights on Missouri vs. Auburn. We can tell you it is leaning Over the total, and it also says one side of the spread hits in more than 50% of simulations! You ABSOLUTELY need to see it before locking in any college football picks.

Who wins Missouri vs. Auburn? And which side of the spread hits more than 50% of the time? ... Join SportsLine right now to find out which side of the Missouri vs. Auburn spread you should be all over Saturday, all from the model on a roll on college football picks!