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Missouri State vs. Middle Tennessee odds, line: 2025 college football picks for Week 7 predictions from proven model

SportsLine's model has locked in its best bets for Wednesday night's Conference USA game between the Missouri State Bears and Middle Tennessee Blue Raiders

ByPublished: Oct 08, 2025 9:44PM UTC . 2 min read

The Missouri State Bears take on the Middle Tennessee Blue Raiders in a key Conference USA matchup on Wednesday night. Missouri State is coming off a 27-22 loss to conference-leading Western Kentucky on Sept. 27, while Middle Tennessee dropped a 24-16 decision to Kennesaw State that same day. The Bears (2-3, 0-1 C-USA), who are tied with MTSU for seventh in the conference, are 1-1 on the road this season. The Blue Raiders (1-4, 0-1 C-USA), who have lost two in a row, are 0-2 on their home field.

Kickoff from Johnny "Red" Floyd Stadium in Murfreesboro, Tenn., is at 7:30 p.m. ET. Middle Tennessee won the only meeting between the teams, posting a 42-19 victory in 1986. The Bears are 1.5-point favorites in the latest Missouri State vs. Middle Tennessee odds, while the over/under for total points scored is 49.5 via SportsLine consensus. The Under has hit in four straight Missouri State games. Missouri State is at -128 on the money line (risk $128 to win $100), while MTSU is at +107 (risk $100 to win $107).

Before making any Missouri State vs. Middle Tennessee picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and is a profitable 38-25 combined on money-line and over/under picks since the beginning of 2024. Anyone following at sportsbooks and on betting apps could have seen STRONG returns!

The model has simulated Missouri State vs. Middle Tennessee 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits in 60% of simulations!

So who wins Missouri State vs. Middle Tennessee, and which side of the spread hits 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!

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Daniel Kohn

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