Mississippi State vs. Wake Forest prediction, odds, time: 2026 Duke's Mayo Bowl picks from proven model

The 2025-26 college football bowl schedule is coming to an end, with Friday's Duke's Mayo Bowl 2026 being the final non-CFP contest. It features the Mississippi State Bulldogs taking on the Wake Forest Demon Deacons in an SEC vs. ACC matchup. The Bulldogs (5-7) enter in on a three-game losing streak, most recently falling to Ole Miss, 38-19, in the Egg Bowl. Wake Forest (8-4) lost its last outing, 49-32, to Duke.

Kickoff is at 8 p.m. ET from Bank of America Stadium in Charlotte, N.C. The Bulldogs are 3.5-point favorites in the latest Wake Forest vs. Mississippi State odds, while the over/under is 53.5.

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Before making any Mississippi State vs. Wake Forest picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times, and it is 31-19 on its top-rated college football money-line picks since the beginning of the 2024 season. 

The model has simulated Wake Forest vs. Mississippi State 10,000 times and the results are in. We can tell you that the model is going Under, and it also says one side of the spread hits almost 60% of the time!

So who wins Mississippi State vs. Wake Forest, and which side of the spread hits almost 60% of the time? Join SportsLine right now to see which side of the Wake Forest vs. Mississippi State spread you need to jump on, all from the computer model that has simulated this game 10,000 times!

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