Minnesota vs. No. 9 Oregon odds, line: 2025 college football picks for Week 12 predictions from proven model

The ninth-ranked Oregon Ducks will look to keep their College Football Playoff hopes alive when they take on the Minnesota Golden Gophers in a key Big Ten Conference matchup on Friday night. Minnesota is coming off a 23-20 win over Michigan State on Nov. 1, while Oregon defeated Iowa 18-16 on Saturday. The Golden Gophers (6-3, 4-2 Big Ten), who are 1-1 against ranked opponents, are 0-3 on the road this season. The Ducks (8-1, 5-1 Big Ten), who have won three in a row, are 4-1 on their home field in 2025.

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Kickoff from Autzen Stadium in Eugene, Ore., is at 9 p.m. ET. Minnesota leads the all-time series 3-1. The Ducks are 26.5-point favorites in the latest Minnesota vs. Oregon odds, while the over/under for total points scored is 44.5 via SportsLine consensus.

Before making any Minnesota vs. Oregon picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of over $2,000 for $100 players on its top-rated college spread football picks. Anyone following could have seen impressive returns.

The model has simulated Minnesota vs. Oregon 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits in nearly 60% of simulations.

So who wins Minnesota vs. Oregon, and which side of the spread hits nearly 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!

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