Michigan vs. Purdue odds, prediction: 2026 Big Ten Conference men's college basketball picks from proven model

Two of the top teams in the Big Ten Conference clash when the top-ranked Michigan Wolverines take on the seventh-ranked Purdue Boilermakers on Tuesday. Michigan is coming off an 86-56 win over UCLA on Saturday, while Purdue defeated Iowa 78-57 that same day. The Wolverines (24-1, 14-1 Big Ten), who lead the conference, have won 10 in a row and are 8-0 on the road this season. The Boilermakers (21-4, 11-3 Big Ten), who are tied for third in the league, are 11-2 on their home floor.

Tip-off from Mackey Arena in West Lafayette, Ind., is set for 6:30 p.m. ET. Purdue leads the all-time series 93-77. Michigan is a 1.5-point favorite in the latest Michigan vs. Purdue odds from DraftKings Sportsbook, while the over/under for total points scored is 156.5. 

Before making any Michigan vs. Purdue picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and entered Week 16 on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on an 13-7 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated Michigan vs. Purdue 10,000 times and the results are in. The model is leaning Over, and it also says one side of the spread hits well over 60% of the time!

So who wins Michigan vs. Purdue, and which side of the spread hits well over 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!