Michigan vs. Nebraska odds, line, time: 2025 college football picks for Week 4 from proven computer model

The No. 21 Michigan Wolverines (2-1) will visit the Nebraska Cornhuskers (3-0) in the Big Ten opener for both schools on Saturday on CBS and Paramount+. Michigan bounced back from its loss to Oklahoma with a resounding 63-3 victory over Central Michigan in Week 3. Meanwhile, Nebraska easily handled an FCS school last week, defeating Houston Christian University, 59-7. The Wolverines have won each of the last four meetings between the teams.

Kickoff is at 3:30 p.m. ET from Memorial Stadium in Lincoln, Neb. The Wolverines are 1-point road favorites in the latest Nebraska vs. Michigan odds, while the over/under for total points scored is 47.5.

Before making any Michigan vs. Nebraska picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

Be sure to watch this game on CBS and Paramount+, where new users can get a free one-week trial. Sign up here.    

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and is a profitable 32-20 combined on money-line and over/under picks since the beginning of 2024. Anyone following could have seen impressive returns!

The model has simulated Nebraska vs. Michigan 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread hits in well over 60% of simulations!

So who wins Michigan vs. Nebraska, and which side of the spread hits well over 60% of the time? Join SportsLine right now to see which side of the Nebraska vs. Michigan spread you need to jump on, all from the computer model that has crushed its college football picks!