Michigan vs. Michigan State odds, prediction: 2026 Big Ten men's college basketball picks from proven model

Two of the Big Ten's top teams clash with first place on the line when the third-ranked Michigan Wolverines battle the seventh-ranked Michigan State Spartans on Friday night. Michigan is coming off a 75-72 win over Nebraska on Tuesday, while Michigan State defeated Rutgers 88-79 that same night. The Wolverines (19-1, 9-1 Big Ten), who are 4-0 against ranked opponents this season, are 5-0 on the road. The Spartans (19-2, 9-1 Big Ten), who are 3-2 against ranked foes, are 11-1 on their home court.

Tip-off from the Breslin Center in East Lansing, Mich., is set for 8 p.m. ET. Michigan leads the all-time series 104-92, but Michigan State holds a 56-38 edge on its home court. Michigan is a 1.5-point favorite in the latest Michigan vs. Michigan State odds from DraftKings Sportsbook, while the over/under for total points scored is 146.5. Before making any Michigan vs. Michigan State picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and entered Week 13 on a sizzling 10-1 run on top-ranked over/under picks dating back to last year, and it is on a 6-0 roll on side picks. Anyone following could have seen HUGE returns!

The model has simulated Michigan vs. Michigan State 10,000 times and the results are in. The model is leaning Over, and it also says one side of the spread hits over 70% of the time!

So who wins Michigan vs. Michigan State, and which side of the spread hits over 70% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!