The No. 2 Michigan Wolverines will open their 2023 season against East Carolina on Saturday afternoon. The Wolverines went 13-1 last year, making a run to the College Football Playoff. They will be without head coach Jim Harbaugh, who is serving a three-game suspension due to NCAA violations. East Carolina is coming off an 8-5 season, including a 53-29 win over Coastal Carolina in the Birmingham Bowl for its first bowl victory since 2013. 

Kickoff at Michigan Stadium in Ann Arbor is set for noon ET. The Wolverines are 36-point favorites in the latest Michigan vs. East Carolina odds, per SportsLine consensus, while the over/under for total points scored is 52.5. 

Before making any East Carolina vs. Michigan picks or college football predictions, you NEED to see the predictions from the SportsLine Projection Model.

The model simulates every FBS college football game 10,000 times. Since its inception, the proprietary computer model has generated a stunning profit of almost $2,500 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen HUGE returns.

The model knows that Michigan defensive coordinator Jesse Minter is going to take over the coaching duties for Harbaugh on Saturday. Offensive coordinator Sherrone Moore is also serving a suspension due to the NCAA violations, so quarterbacks coach Kirk Campbell is in charge of calling the plays. Michigan is led by star running back Blake Corum, who finished seventh in Heisman Trophy voting last season after rushing for 1,463 yards before missing the final 3.5 games of the season due to a knee injury. 

The model also knows that East Carolina is coming off its first bowl win since 2013, but it lost four key offensive players from that team. Head coach Mike Houston has yet to announce his starting quarterback, with Mason Garcia and Alex Flinn competing for the starting gig. This is East Carolina's first all-time meeting with Michigan. 

Now, the model has set its sights on Michigan vs. East Carolina. We can tell you it is leaning Over on the total, and it also says one side of the spread hits over 50% of the time! You ABSOLUTELY need to see it before locking in any college football picks!

Who wins East Carolina vs. Michigan, and which side of the spread hits over 50% of the time? ... Join SportsLine right now to find out which side of the Michigan vs. East Carolina spread you should be all over on Saturday, all from the model that's up nearly $2,500 on top-rated CFB spread picks!