Michigan vs. Arizona odds, prediction: 2026 NCAA Tournament picks from proven model

A spot in the NCAA Tournament men's national championship game is on the line when the West Region champion Arizona Wildcats take on the Midwest Region champion Michigan Wolverines on Saturday. Arizona advanced with a 79-64 win over Purdue in the Elite Eight, while Michigan cruised past Tennessee 95-62. The Wildcats (36-2), who won the Big 12 Conference regular season at 16-2 and the conference tournament championship, are 14-2 against ranked opponents. The Wolverines (35-3), who won the Big Ten Conference regular season at 19-1, are 11-2 against ranked foes.

Tip-off from Lucas Oil Stadium in Indianapolis is set for 8:49 p.m. ET. Arizona leads the all-time series 9-2, including an 80-62 win in their last meeting on Nov. 21, 2021. Michigan is a 1.5-point favorite in the latest Michigan vs. Arizona odds, while the over/under for total points scored is 157.5. 

Before making any Michigan vs. Arizona picks, you NEED to see the basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times. It entered the 2026 Final Four on a sizzling 11-1 run on its top-rated over/under college basketball picks dating back to last season, and is on a 28-22 run on top-rated CBB side picks. 

The model has simulated Michigan vs. Arizona 10,000 times and the results are in. The model is going Under on the total, and it also says one side of the spread has all the value!

So who wins Michigan vs. Arizona, and which side of the spread has all the value? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!