Michigan State vs. Wisconsin odds, prediction: 2026 Big Ten Conference men's college basketball picks from proven model

Teams vying for an upper-third finish in the Big Ten Conference clash when the No. 10 Michigan State Spartans battle the Wisconsin Badgers in a key matchup on Friday night. Michigan State is coming off an 85-82 home overtime win over Illinois on Saturday, while Wisconsin defeated Illinois 92-90 in overtime on Tuesday in Champaign, Ill. The Spartans (20-4, 10-3 Big Ten), who are tied for third in the conference, are 4-2 on the road this season. The Badgers (17-7, 9-4 Big Ten), who are tied for sixth in the league, are 12-2 on their home court.

Tip-off from the Kohl Center in Madison, Wis., is set for 8 p.m. ET. Michigan State leads the all-time series 87-70, but Wisconsin has won three of the past four meetings. Michigan State is a 1.5-point favorite in the latest Michigan State vs. Wisconsin odds from DraftKings Sportsbook, while the over/under for total points scored is 145.5. 

Before making any Michigan State vs. Wisconsin picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and entered Week 15 on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on an 11-5 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated Michigan State vs. Wisconsin 10,000 times and the results are in. The model is leaning Over, and it also says one side of the spread hits 60% of the time!

So who wins Michigan State vs. Wisconsin, and which side of the spread hits 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!