Miami vs. Ohio State odds, line: 2025 college football picks for Cotton Bowl and College Football Playoff quarterfinal matchup from proven model

The 10th-ranked Miami (Fla.) Hurricanes battle the second-ranked Ohio State Buckeyes in a College Football Playoff quarterfinal matchup at the Cotton Bowl on Wednesday. Miami is coming off a 10-3 win at Texas A&M in a CFP first-round matchup on Dec. 20, while Ohio State fell 13-10 to Indiana in the Big Ten Championship Game on Dec. 6. The Hurricanes (11-2), who tied for second in the Atlantic Coast Conference, are 4-0 against ranked opponents this season. The Buckeyes (12-1), who tied for first in the Big Ten Conference, are the defending national champions and are 3-1 against ranked foes in 2025.

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Kickoff from AT&T Stadium in Arlington, Texas, is at 7:30 p.m. ET. The all-time series is tied 2-2. The Buckeyes are 9.5-point favorites in the latest Miami vs. Ohio State odds, while the over/under for total points scored is 40.5 via SportsLine consensus. 

Before making any Miami vs. Ohio State picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times, and it is 31-19 on rated college football money-line picks since the beginning of the 2024 season. 

The model has simulated Miami vs. Ohio State 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits over 50% of simulations!

So who wins Miami vs. Ohio State, and which side of the spread hits over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times! 

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