Miami vs. Missouri odds, prediction: 2026 NCAA Tournament picks from proven model

The opening round of the 2026 NCAA Tournament concludes Friday night, with No. 7 Miami vs. No. 10 Missouri in the West Region. Miami (25-8) returns to the NCAA Tournament for the first time since 2023, when the Hurricanes made the Final Four as a No. 5 seed. Meanwhile, Missouri returns to March Madness for the second straight season, entering at 20-12 on the season. 

Tipoff from the Enterprise Center in St. Louis, Missouri, is scheduled for 10:10 p.m. ET. The Hurricanes are 1.5-point favorites in the latest Miami vs. Missouri odds, with the over/under at 147.5. 

Before making any Missouri vs. Miami picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times. It entered the 2026 NCAA Tournament on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on a 28-22 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated Miami vs. Missouri 10,000 times and the results are in. The model is going Over on the total, and it also says one side of the spread hits well over 50% of the time!

So who wins Missouri vs. Miami, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!