Miami (OH) vs. SMU odds, prediction: 2026 NCAA Tournament picks from proven model

The Miami (OH) Redhawks battle the SMU Mustangs in a First Four matchup in the Midwest regional of the NCAA Tournament on Wednesday night. The winner will be the 11th seed and will face the sixth-seeded Tennessee Volunteers on Friday. The Miami (OH) Redhawks (31-1) suffered their one and only defeat this season in an 87-83 loss to UMass in the first round of the Mid-American Conference tournament. SMU was able to get into the tournament with a grueling nonconference schedule. The Redhawks have won four of five games, while the Mustangs have lost four of five games. 

Tip-off from UD Arena in Dayton, Ohio, is set for 9:15 p.m. ET. Miami (OH) holds a 2-0 all-time series lead over SMU. The RedHawks will have a massive home-court advantage with the University of Dayton Arena being only one hour from Miami's campus in Oxford, Ohio. SMU is a 6.5-point favorite in the latest Miami (OH) vs SMU odds from DraftKings Sportsbook, while the over/under for total points scored is 164.5. 

Before making any SMU vs. Miami (OH) picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times. It entered the 2026 NCAA Tournament on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on a 28-22 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated Miami (OH) vs SMU 10,000 times and the results are in. The model is going Over on the total, and it also says one side of the spread hits well over 60% of the time!

So who wins Miami (OH) vs SMU, and which side of the spread hits well over 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!