Miami (Fla.) vs. Purdue odds, prediction: 2026 NCAA Tournament picks from proven model

The seventh-seeded Miami (Fla.) Hurricanes face the second-seeded Purdue Boilermakers in the second round of the NCAA Tournament West Region on Sunday. Miami advanced with an 80-66 win over Missouri in Friday's first-round matchup, while Purdue defeated Queens University 104-71 that same day. The Hurricanes (26-8), who finished third in the Atlantic Coast Conference at 13-5, have won three of their last five. The Boilermakers (28-8), who tied for sixth in the Big Ten Conference at 13-7, have won five in a row, including the Big Ten Conference Tournament title.

Tip-off from Enterprise Center in St. Louis is set for 12:10 p.m. ET. Purdue leads the all-time series 3-1, but Miami won the last meeting, a 58-54 decision in the 2020 ACC/Big Ten Challenge. Purdue is a 7.5-point favorite in the latest Miami vs. Purdue odds, while the over/under for total points scored is 147.5. Before making any Miami vs. Purdue picks, you NEED to see the basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times. It entered the 2026 NCAA Tournament on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on a 28-22 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated Miami vs. Purdue 10,000 times and the results are in. The model is going Over on the total, and it also says one side of the spread hits in well over 50% of the simulations!

So who wins Miami vs. Purdue, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!