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Mets vs. Pirates odds, line, start time, picks, best bets for June 27 National League matchup from proven model

SportsLine's projection model, which is on a 41-32 roll on top-rated MLB picks, has locked in its MLB picks for the Mets vs. Pirates on Friday

ByPublished: Jun 27, 2025 7:43PM UTC . 2 min read

Teams looking to turn around their recent fortunes meet when the New York Mets battle the Pittsburgh Pirates in a key National League matchup on Friday. Both teams are 3-7 in their last 10 games. The Mets (48-34), who have not won a series since June 10-12, are 19-22 on the road this season. The Pirates (32-50), who are fifth in the NL Central, are 20-21 on their home field in 2025.

First pitch from PNC Park in Pittsburgh is set for 6:40 p.m. ET. The Mets have won seven of the last 10 meetings. New York is a -140 favorite on the money line (risk $140 to win $100) in the latest Mets vs. Pirates odds from DraftKings Sportsbook, while the total number of runs Vegas thinks will be scored, or the over/under, is 8 in the latest MLB odds. 

Before you make any Mets vs. Pirates picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 14 of the 2025 MLB season on a profitable 41-32 run on top-rated MLB picks. It has excelled making home run prop picks this season, returning more than 22 units of profit. Anybody following could have seen strong returns!

The model has simulated Mets vs. Pirates 10,000 times and the results are in. We can tell you the model is going Over on the run total, and it also says one side of the money line has all the value!

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Daniel Kohn

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