The Maryland Terrapins and Virginia Tech Hokies take their turn in the 2021 ACC/Big Ten Challenge on Wednesday night at 7:15 p.m. ET. After starting the season with five consecutive wins, the Hokies have lost back-to-back games against Memphis and Xavier. Maryland is coming off of a loss as well, and fell to Louisville on November 27, 63-55.

The Terrapins are favored by a single point in the latest Maryland vs. Virginia Tech odds from Caesars Sportsbook, and the over-under is set at 132. Before you make any Virginia Tech vs. Maryland picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $2,100 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen HUGE returns.

Now, it has simulated Maryland vs. Virginia Tech 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 60 percent of simulations. You absolutely need to see it before locking in your own picks.

Who wins Maryland vs. Virginia Tech? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks ... If you're already a member, see the picks below!