Maryland vs. Buffalo odds, line, spread: Proven model reveals college football picks, predictions for Week 1, 2022

The Maryland Terrapins will take on the Buffalo Bulls at noon ET on Saturday at Capital One Field at Maryland Stadium. Buffalo lost its final four games last year, while Maryland closed the season on a two-game winning streak. The Terrapins are favored by 24 points in the latest Maryland vs. Buffalo odds from Caesars Sportsbook, while the over/under is set at 65. 

Before you make any Buffalo vs. Maryland picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,600 for $100 players on its top-rated college football picks against the spread. It enters Week 1 of the 2022 college football season on a 45-32 run on all top-rated college football side picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, it has simulated Maryland vs. Buffalo 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in well over 70% of simulations. You absolutely need to see it before locking in your own picks.

So who wins Maryland vs. Buffalo? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks.