The Minnesota Twins look to earn the four-game series split when they battle the Seattle Mariners in a key American League matchup on Thursday afternoon. The Mariners (41-38), who are second in the AL West, are 21-19 on the road this season. The Twins (38-42), who have lost 11 of 13, are 21-17 on their home field in 2025.

First pitch Target Field in Minneapolis is set for 1:10 p.m. ET. The Mariners have won five of the last nine meetings. Minnesota is a -120 favorite on the money line (risk $120 to win $100) in the latest Mariners vs. Twins odds from DraftKings Sportsbook, while the total number of runs Vegas thinks will be scored, or the over-under, is 8.5 in the latest MLB odds. 

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