Mariners vs. Orioles odds, line, start time, picks, best bets for August 14 matchup from proven model

A series win will be on the line when the Seattle Mariners meet the Baltimore Orioles in the third and deciding game of their series on Thursday afternoon. The Mariners (67-54), who had an eight-game winning streak stopped, are 30-29 on the road this season. The Orioles (54-66), who snapped a three-game losing streak, are 29-30 on their home field in 2025.

First pitch from Oriole Park at Camden Yards in Baltimore is set for 1:05 p.m. ET. The Orioles have won seven of the past nine meetings with the Mariners. Seattle is a -131 favorite on the money line (risk $131 to win $100) in the latest Mariners vs. Orioles odds from DraftKings Sportsbook, while the total number of runs Vegas thinks will be scored, or the over-under, is 9.5 in the latest MLB odds. 

Before you make any Mariners vs. Orioles picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 21 of the 2025 MLB season a profitable 31-23 on top-rated MLB money-line picks. It has excelled making home run prop picks this season, returning nearly 60 units of profit. Anybody following could have seen strong returns!

The model has simulated Mariners vs. Orioles 10,000 times and the results are in. We can tell you the model is going Under on the run total, and it also says one side of the money line has all the value!

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